Compound Detail
CHEMBL149401
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Basic Information
| ChEMBL ID | CHEMBL149401 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FGUWJWYUTCLUGU-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
238.2
MW (Da)
2.72
ALogP
3
HBA
1
HBD
55.1
PSA (Ų)
0.75
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta CHEMBL2749 | IC50 | 4.3 | 4.3 | 50000.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 4.3 | 4.3 | 50000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta | IC50 | = | 50000.0 | nM | 4.3 | Inhibition of phosphorylation of a random glutamate/tyrosine copolymer in lysate... | 9876115 |
| Fibroblast growth factor receptor 1 | IC50 | = | 50000.0 | nM | 4.3 | Inhibition of phosphorylation of a random glutamate/tyrosine copolymer in lysate... | 9876115 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9876115 | 10.1021/jm9804681 | Platelet-derived growth factor receptor beta | 1 |
| 9876115 | 10.1021/jm9804681 | Fibroblast growth factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine