Compound Detail
CHEMBL1497797
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Basic Information
| ChEMBL ID | CHEMBL1497797 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QXOKSTGXTNUTRX-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
371.3
MW (Da)
5.47
ALogP
3
HBA
1
HBD
38.1
PSA (Ų)
0.66
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.55
IC50 1 meas. best 5.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Zinc finger protein GLI1 CHEMBL5007 | IC50 | 5.7 | 5.7 | 2020.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 5.55 | 5.55 | 2820.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Zinc finger protein GLI1 | IC50 | = | 2020.0 | nM | 5.7 | PubChem BioAssay. Dose response confirmation of uHTS antagonist hits from Gli-SU... | - |
| Unchecked | EC50 | = | 2820.0 | nM | 5.55 | PubChem BioAssay. Leishmania major promastigote EC50 determinations. (Class of... | - |
Data from ChEMBL 36 via Core Engine