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Target Snapshot

CHEMBL5007 Target Snapshot

Zinc finger protein GLI1 · SINGLE PROTEIN · Mus musculus

440Compounds
9Assays
1Approved Drugs
447.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P47806. Use UniProt P47806 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P47806 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Zinc finger protein GLI1 as ChEMBL target CHEMBL5007, mapped to UniProt P47806. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Zinc finger protein GLI1
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL5007
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P47806
Zinc finger protein GLI1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Zinc finger protein GLI1 is the right protein anchor across sources, using UniProt P47806 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelZinc finger protein GLI1
UniProt AccessionP47806
Component TypeProtein
Sequence Length1111 aa

Zinc finger protein GLI1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Zinc finger protein GLI1, mapped to UniProt P47806. Sequence length is 1111 aa.

Mapped IDP47806
Review nameZinc finger protein GLI1
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC50447.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1393367 7.64 IC50 23.0 Preclinical
CHEMBL3187872 7.62 IC50 24.0 Preclinical
CHEMBL1438842 7.57 IC50 27.0 Preclinical
CHEMBL3184876 7.46 IC50 35.0 Preclinical
CHEMBL3185423 6.75 IC50 176.0 Preclinical
CHEMBL1543258 6.43 IC50 368.0 Preclinical
CHEMBL1336211 6.38 IC50 421.0 Preclinical
CHEMBL1509493 6.27 IC50 535.0 Preclinical
CHEMBL3185613 6.25 IC50 556.0 Preclinical
CHEMBL1581759 6.21 IC50 619.0 Preclinical
Distribution

pChEMBL Value Distribution

204
5.0
37
5.5
15
6.0
2
6.5
5
7.0
4
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

9
Total Assays
311
Tested Compounds
2
Assay Types
Binding — 6 assays, 9 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 0
single protein format 3 9 4.7
Functional — 3 assays, 311 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 3 311 5.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine