Compound Detail
CHEMBL1393367
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Basic Information
| ChEMBL ID | CHEMBL1393367 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BRHZZEILTNZERC-UHFFFAOYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
282.4
MW (Da)
2.72
ALogP
4
HBA
1
HBD
58.1
PSA (Ų)
0.94
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Zinc finger protein GLI1 CHEMBL5007 | IC50 | 7.64 | 7.26 | 23.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Zinc finger protein GLI1 | IC50 | = | 23.0 | nM | 7.64 | PubChem BioAssay. SAR analysis of small molecule antagonists of Gli-SUFU in a lu... | - |
| Zinc finger protein GLI1 | IC50 | = | 24.2 | nM | 7.62 | PubChem BioAssay. SAR analysis of small molecule antagonists of Gli-SUFU in a lu... | - |
| Zinc finger protein GLI1 | IC50 | = | 56.6 | nM | 7.25 | PubChem BioAssay. SAR analysis of small molecule antagonists of Gli-SUFU in a lu... | - |
| Zinc finger protein GLI1 | IC50 | = | 294.0 | nM | 6.53 | PubChem BioAssay. Dose response confirmation of uHTS antagonist hits from Gli-SU... | - |
Data from ChEMBL 36 via Core Engine