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Compound Detail

CHEMBL1503209

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Cc1nn(CCc2nn[nH]n2)c2nc(-c3ccc(C4CCCCC4)cc3)cc(C(F)(F)F)c12

Basic Information

ChEMBL ID CHEMBL1503209
Phase Preclinical
Structure Type MOL
InChI Key WBBFHCPJBLVPHP-UHFFFAOYSA-N
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

455.5
MW (Da)
5.23
ALogP
6
HBA
1
HBD
85.2
PSA (Ų)
0.45
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H24F3N7
MW 455.49
Aromatic Rings 4
Heavy Atoms 33
NP-Likeness -1.64

Activity Summary

IC50 2 meas. best 4.91
EC50 1 meas. best 4.42

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Envelope glycoprotein gp160
CHEMBL1293311
IC50 4.91 4.91 12400.0 1
Unchecked
CHEMBL612545
IC50 4.66 4.66 21660.0 1
Protein RecA
CHEMBL1741171
EC50 4.42 4.42 38100.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine