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Compound Detail

CHEMBL150450

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FC(F)(F)CCCCSc1nsnc1[C@@H]1CN2CCC[C@@H]1C2

Basic Information

ChEMBL ID CHEMBL150450
Phase Preclinical
Structure Type MOL
InChI Key RQAHWVOGBRVHRZ-GHMZBOCLSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

351.5
MW (Da)
4.17
ALogP
5
HBA
0
HBD
29.0
PSA (Ų)
0.57
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H20F3N3S2
MW 351.46
Aromatic Rings 1
Heavy Atoms 22
NP-Likeness -0.56

Activity Summary

Ki 1 meas. best 9.62

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
Ki 9.62 9.62 0.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9046345 10.1021/jm9602470 Mustela putorius furo 2
9046345 10.1021/jm9602470 Muscarinic acetylcholine receptor 1
9046345 10.1021/jm9602470 Mus musculus 1

Data from ChEMBL 36 via Core Engine