Assay Detail
Binding
CHEMBL752168
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Binding affinity against Muscarinic acetylcholine receptors using [3H]oxotremorine-M as radioligand in rat cortex
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: potential application for the treatment of irritable bowel syndrome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 8.84 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150450 | — | — | 1 | 9.62 |
| CHEMBL436075 | — | — | 1 | 9.48 |
| CHEMBL153723 | — | — | 1 | 9.44 |
| CHEMBL136807 | VEDACLIDINE | 2.0 | 1 | 9.40 |
| CHEMBL150293 | — | — | 1 | 9.38 |
| CHEMBL153478 | — | — | 1 | 9.36 |
| CHEMBL343731 | — | — | 1 | 9.35 |
| CHEMBL115648 | — | — | 1 | 9.30 |
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 9.05 |
| CHEMBL357279 | — | — | 1 | 9.04 |
| CHEMBL318403 | — | — | 1 | 9.00 |
| CHEMBL101054 | — | — | 1 | 8.85 |
| CHEMBL153150 | — | — | 1 | 8.52 |
| CHEMBL153031 | — | — | 1 | 8.46 |
| CHEMBL332700 | — | — | 1 | 8.40 |
| CHEMBL150501 | — | — | 1 | 8.02 |
| CHEMBL152892 | — | — | 1 | 8.00 |
| CHEMBL152919 | — | — | 1 | 7.75 |
| CHEMBL154923 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150450 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL436075 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL153723 | — | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL136807 | VEDACLIDINE | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL150293 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL153478 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL343731 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL115648 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL517712 | ATROPINE | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL357279 | — | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL318403 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL101054 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL153150 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL153031 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL332700 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL150501 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL152892 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL152919 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL154923 | — | Ki | = | 25.0 | nM | 7.60 |