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Compound Detail

CHEMBL115648

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CCCCSc1nccnc1C1CN2CCC1CC2

Basic Information

ChEMBL ID CHEMBL115648
Phase Preclinical
Structure Type MOL
InChI Key XUTVZEFLAKJGLE-UHFFFAOYSA-N
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

277.4
MW (Da)
3.18
ALogP
4
HBA
0
HBD
29.0
PSA (Ų)
0.61
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H23N3S
MW 277.44
Aromatic Rings 1
Heavy Atoms 19
NP-Likeness -0.37

Activity Summary

IC50 2 meas. best 9.4
Ki 1 meas. best 9.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL276
IC50 9.4 9.35 0.4 2
Muscarinic acetylcholine receptor
CHEMBL1907609
Ki 9.3 9.3 0.5 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9046345 10.1021/jm9602470 Mustela putorius furo 2
7658434 10.1021/jm00018a007 Muscarinic acetylcholine receptor M1 2
9046345 10.1021/jm9602470 Muscarinic acetylcholine receptor 1
9046345 10.1021/jm9602470 Mus musculus 1
7658434 10.1021/jm00018a007 A9 1
7658434 10.1021/jm00018a007 Mus musculus 1

Data from ChEMBL 36 via Core Engine