Compound Detail
CHEMBL1520233
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Basic Information
| ChEMBL ID | CHEMBL1520233 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PQGSYPIKDTVBJW-UHFFFAOYSA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
362.4
MW (Da)
3.75
ALogP
6
HBA
1
HBD
98.5
PSA (Ų)
0.50
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.01
IC50 2 meas. best 4.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Large ribosomal subunit protein eL19A CHEMBL1741172 | EC50 | 5.01 | 5.01 | 9714.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.82 | 4.745 | 15090.0 | 2 |
| Mitochondrial peptide methionine sulfoxide reductase CHEMBL2007622 | EC50 | 4.26 | 4.26 | 54732.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Large ribosomal subunit protein eL19A | EC50 | = | 9714.0 | nM | 5.01 | PUBCHEM_BIOASSAY: Dose Response of TOR pathway GFP-fusion proteins in Saccharomy... | - |
| Unchecked | IC50 | = | 15090.0 | nM | 4.82 | PUBCHEM_BIOASSAY: A counter screen for small molecule screen for inhibitors of t... | - |
| Unchecked | IC50 | = | 21640.0 | nM | 4.67 | PUBCHEM_BIOASSAY: A small molecule screen for inhibitors of the PhoP region in S... | - |
| Mitochondrial peptide methionine sulfoxide reductase | EC50 | = | 54732.0 | nM | 4.26 | PUBCHEM_BIOASSAY: Absorbance-based biochemical high throughput dose response ass... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27544588 | 10.1016/j.bmc.2016.08.004 | Autotaxin | 1 |
Data from ChEMBL 36 via Core Engine