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Compound Detail

CHEMBL152867

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Cn1c(CN2CCN(c3ccccc3Cl)CC2)ccc1CN1CCCC1=O

Basic Information

ChEMBL ID CHEMBL152867
Phase Preclinical
Structure Type MOL
InChI Key RIWSLMCCDAXDQC-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

386.9
MW (Da)
3.12
ALogP
4
HBA
0
HBD
31.7
PSA (Ų)
0.79
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H27ClN4O
MW 386.93
Aromatic Rings 2
Heavy Atoms 27
NP-Likeness -1.38

Activity Summary

Ki 1 meas. best 7.28

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-1
CHEMBL1907610
Ki 7.28 7.28 53.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1346653 10.1021/jm00081a018 Rattus norvegicus 1
1346653 10.1021/jm00081a018 D(2) dopamine receptor 1
1346653 10.1021/jm00081a018 Adrenergic receptor alpha-1 1

Data from ChEMBL 36 via Core Engine