Assay Detail
Binding
CHEMBL645698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for its binding affinity towards Alpha-1 adrenergic receptor by displacing [3H]WB-4101 radioligand in rat cerebral cortex
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Pyrrole mannich bases as potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 7.32 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434512 | — | — | 1 | 8.28 |
| CHEMBL345506 | — | — | 1 | 8.14 |
| CHEMBL428175 | RWJ-25730 | — | 1 | 8.09 |
| CHEMBL347334 | — | — | 1 | 7.95 |
| CHEMBL348002 | — | — | 1 | 7.80 |
| CHEMBL152311 | — | — | 1 | 7.79 |
| CHEMBL153136 | — | — | 1 | 7.76 |
| CHEMBL357286 | — | — | 1 | 7.70 |
| CHEMBL346168 | — | — | 1 | 7.68 |
| CHEMBL347056 | — | — | 1 | 7.64 |
| CHEMBL348014 | — | — | 1 | 7.58 |
| CHEMBL348241 | — | — | 1 | 7.56 |
| CHEMBL422 | TRIFLUOPERAZINE | 4.0 | 1 | 7.53 |
| CHEMBL347782 | — | — | 1 | 7.45 |
| CHEMBL153335 | — | — | 1 | 7.42 |
| CHEMBL152336 | — | — | 1 | 7.37 |
| CHEMBL153490 | — | — | 1 | 7.35 |
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 7.30 |
| CHEMBL152867 | — | — | 1 | 7.28 |
| CHEMBL152458 | — | — | 1 | 7.27 |
| CHEMBL152204 | — | — | 1 | 7.20 |
| CHEMBL152424 | — | — | 1 | 7.00 |
| CHEMBL151966 | — | — | 1 | 6.87 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 6.86 |
| CHEMBL152617 | — | — | 1 | 6.85 |
| CHEMBL152776 | — | — | 1 | 6.78 |
| CHEMBL357532 | — | — | 1 | 6.58 |
| CHEMBL346459 | — | — | 1 | 6.36 |
| CHEMBL9666 | — | — | 1 | 6.29 |
| CHEMBL153161 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434512 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL345506 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL428175 | RWJ-25730 | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL347334 | — | Ki | = | 11.3 | nM | 7.95 |
| CHEMBL348002 | — | Ki | = | 15.7 | nM | 7.80 |
| CHEMBL152311 | — | Ki | = | 16.3 | nM | 7.79 |
| CHEMBL153136 | — | Ki | = | 17.4 | nM | 7.76 |
| CHEMBL357286 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL346168 | — | Ki | = | 20.8 | nM | 7.68 |
| CHEMBL347056 | — | Ki | = | 23.1 | nM | 7.64 |
| CHEMBL348014 | — | Ki | = | 26.6 | nM | 7.58 |
| CHEMBL348241 | — | Ki | = | 27.5 | nM | 7.56 |
| CHEMBL422 | TRIFLUOPERAZINE | Ki | = | 29.3 | nM | 7.53 |
| CHEMBL347782 | — | Ki | = | 35.9 | nM | 7.45 |
| CHEMBL153335 | — | Ki | = | 38.2 | nM | 7.42 |
| CHEMBL152336 | — | Ki | = | 43.1 | nM | 7.37 |
| CHEMBL153490 | — | Ki | = | 44.9 | nM | 7.35 |
| CHEMBL267777 | RITANSERIN | Ki | = | 49.5 | nM | 7.30 |
| CHEMBL152867 | — | Ki | = | 53.1 | nM | 7.28 |
| CHEMBL152458 | — | Ki | = | 53.9 | nM | 7.27 |
| CHEMBL152204 | — | Ki | = | 63.7 | nM | 7.20 |
| CHEMBL152424 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL151966 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL49 | BUSPIRONE | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL152617 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL152776 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL357532 | — | Ki | = | 264.0 | nM | 6.58 |
| CHEMBL346459 | — | Ki | = | 436.0 | nM | 6.36 |
| CHEMBL9666 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL153161 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL153263 | — | Ki | > | 100.0 | nM | - |
| CHEMBL267044 | LEVOSULPIRIDE | Ki | > | 1000.0 | nM | - |
| CHEMBL346881 | — | Ki | > | 100.0 | nM | - |
| CHEMBL153219 | — | Ki | > | 1000.0 | nM | - |