Compound Detail
CHEMBL153990
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Basic Information
| ChEMBL ID | CHEMBL153990 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HDSAIJZBOBVWLA-GUDVDZBRSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
13
Publications
0
Known Names
Molecular Properties
334.3
MW (Da)
2.98
ALogP
5
HBA
2
HBD
71.5
PSA (Ų)
0.62
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.69
Target Activity Profile
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| BV-2 | IC50 | = | 2050.0 | nM | 5.69 | Inhibition of LPS-induced nitric oxide production in mouse BV2 cells pretreated ... | 27592135 |
| Unchecked | IC50 | = | 24000.0 | nM | 4.62 | In vitro inhibitory activity in the fMLP-stimulated phospholipase (PLD) assay | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27592135 | 10.1016/j.bmcl.2016.08.019 | NON-PROTEIN TARGET | 5 |
| 25237727 | 10.1021/np400988a | NON-PROTEIN TARGET | 3 |
| - | 10.1016/0960-894X(96)00074-1 | Unchecked | 1 |
| 25237727 | 10.1021/np400988a | Pseudomonas | 1 |
| 25237727 | 10.1021/np400988a | Ralstonia solanacearum | 1 |
| 25237727 | 10.1021/np400988a | Staphylococcus haemolyticus | 1 |
| 25237727 | 10.1021/np400988a | Agrobacterium tumefaciens | 1 |
| 25237727 | 10.1021/np400988a | Bacillus subtilis | 1 |
| 25237727 | 10.1021/np400988a | Xanthomonas vesicatoria | 1 |
| 25237727 | 10.1021/np400988a | Pyricularia oryzae | 1 |
| 25237727 | 10.1021/np400988a | A549 | 1 |
| 25237727 | 10.1021/np400988a | A2780 | 1 |
| 27592135 | 10.1016/j.bmcl.2016.08.019 | BV-2 | 1 |
Data from ChEMBL 36 via Core Engine