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Compound Detail

CHEMBL1540717

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CCCC1O[C@@H]2CC3C4CCC5=CC(=O)C=C[C@]5(C)C4C(OC(C)=O)C[C@]3(C)[C@]2(C(=O)COC(C)=O)O1

Basic Information

ChEMBL ID CHEMBL1540717
Phase Preclinical
Structure Type MOL
InChI Key LXXJBYQKJRJLNP-BVGPSFMHSA-N
4
Targets
5
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

514.6
MW (Da)
3.86
ALogP
8
HBA
0
HBD
105.2
PSA (Ų)
0.49
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C29H38O8
MW 514.62
Aromatic Rings 0
Heavy Atoms 37
NP-Likeness 2.20

Activity Summary

EC50 5 meas. best 5.33

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Peroxisome proliferator-activated receptor gamma/Nuclear receptor coactivator 3
CHEMBL2095161
EC50 5.33 5.33 4657.0 1
Peroxisome proliferator-activated receptor gamma/Nuclear receptor coactivator 1
CHEMBL2095162
EC50 5.18 5.18 6649.0 1
Peroxisome proliferator-activated receptor gamma/Nuclear receptor coactivator 2
CHEMBL2095163
EC50 5.06 5.06 8713.0 1
Unchecked
CHEMBL612545
EC50 4.73 4.695 18750.0 2

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine