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Compound Detail

CHEMBL1571034

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COc1cc(OC)c(-c2c3cc(O)c(=O)cc-3oc3cc(O)c(O)cc23)cc1OC

Basic Information

ChEMBL ID CHEMBL1571034
Phase Preclinical
Structure Type MOL
InChI Key JUNRINYOIHIGJU-UHFFFAOYSA-N
6
Targets
8
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

410.4
MW (Da)
3.71
ALogP
8
HBA
3
HBD
118.6
PSA (Ų)
0.34
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H18O8
MW 410.38
Aromatic Rings 2
Heavy Atoms 30
NP-Likeness 0.92

Activity Summary

IC50 6 meas. best 6.14
EC50 2 meas. best 5.07

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Ras and Rab interactor 1/Tyrosine-protein kinase ABL1
CHEMBL3885630
IC50 6.14 6.14 724.2 1
Beta-lactamase
CHEMBL1293260
IC50 5.67 5.67 2126.0 1
Beta Lactamase
CHEMBL1293246
IC50 5.29 5.29 5114.0 1
Beta-lactamase
CHEMBL1293244
IC50 5.25 5.25 5620.0 1
Unchecked
CHEMBL612545
IC50 5.15 5.15 7140.0 1
Unchecked
CHEMBL612545
EC50 5.07 4.97 8540.0 2
Voltage-gated N-type calcium channel alpha-1B subunit/Amyloid beta A4 precursor protein-binding family A member 1
CHEMBL2097170
IC50 4.9 4.9 12500.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine