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Compound Detail

CHEMBL158589

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C[C@@H]1O[C@H](OC(=O)C(C)(C)C)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]21

Basic Information

ChEMBL ID CHEMBL158589
Phase Preclinical
Structure Type MOL
InChI Key VGEVZGPUSONIIS-FCWAOUHXSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

431.7
MW (Da)
5.81
ALogP
4
HBA
0
HBD
38.8
PSA (Ų)
0.42
QED
1
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H45NO3
MW 431.66
Aromatic Rings 0
Heavy Atoms 31
NP-Likeness 1.19

Activity Summary

Kd 2 meas. best 6.33

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M2
CHEMBL309
Kd 6.33 6.33 464.0 1
Muscarinic acetylcholine receptor M1
CHEMBL216
Kd 5.6 5.6 2520.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/0960-894X(94)00459-S Muscarinic acetylcholine receptor M1 1
- 10.1016/0960-894X(94)00459-S Muscarinic acetylcholine receptor M2 1
- 10.1016/0960-894X(94)00459-S Muscarinic acetylcholine receptors; M1 & M2 1

Data from ChEMBL 36 via Core Engine