Compound Detail
CHEMBL159660
ALPHAMETHADOL 🧪 Phase II
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL159660 |
| Name | ALPHAMETHADOL |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | QIRAYNIFEOXSPW-YLJYHZDGSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
4
Known Names
Molecular Properties
311.5
MW (Da)
4.08
ALogP
2
HBA
1
HBD
23.5
PSA (Ų)
0.83
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
Ki 2 meas. best 6.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Opioid receptor CHEMBL2094129 | Ki | 6.64 | 6.64 | 230.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Opioid receptor | Ki | = | 230.0 | nM | 6.64 | Compound was evaluated for the inhibition of [3H]- naloxone opiate receptor bind... | 6268789 |
| Opioid receptor | Ki | = | 230.0 | nM | 6.64 | Inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane i... | 6268789 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 6268789 | 10.1021/jm00139a030 | Opioid receptor | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 7097722 | 10.1021/jm00348a016 | Mu-type opioid receptor | 1 |
Data from ChEMBL 36 via Core Engine