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Compound Detail

CHEMBL1602676

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COc1cc(/C=C/c2nnc3c4ccccc4ncn23)cc(OC)c1OC

Basic Information

ChEMBL ID CHEMBL1602676
Phase Preclinical
Structure Type MOL
InChI Key AUJIZOSZNXPDIY-CMDGGOBGSA-N
1
Targets
6
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

362.4
MW (Da)
3.47
ALogP
7
HBA
0
HBD
70.8
PSA (Ų)
0.54
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H18N4O3
MW 362.39
Aromatic Rings 4
Heavy Atoms 27
NP-Likeness -0.58

Activity Summary

IC50 4 meas. best 5.35
EC50 2 meas. best 5.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 5.35 4.9625 4470.0 4
Unchecked
CHEMBL612545
EC50 5.05 4.795 8837.0 2

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine