Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL1603825

SCANDENIN
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
COc1c(CC=C(C)C)c2c(c3oc(=O)c(-c4ccc(O)cc4)c(O)c13)C=CC(C)(C)O2

Basic Information

ChEMBL ID CHEMBL1603825
Name SCANDENIN
Phase Preclinical
Structure Type MOL
InChI Key AAKJUGSASOCUFQ-UHFFFAOYSA-N
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

434.5
MW (Da)
5.57
ALogP
6
HBA
2
HBD
89.1
PSA (Ų)
0.41
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C26H26O6
MW 434.49
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness 2.30

Activity Summary

IC50 2 meas. best 6.13
Ki 2 meas. best 6.25

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
Ki 6.25 6.25 560.0 1
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
Ki 6.23 6.23 590.0 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
IC50 6.13 6.13 741.3 1
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
IC50 5.97 5.97 1071.5 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19969457 10.1016/j.bmcl.2009.11.103 Achaea janata 20
21314138 10.1021/jf104411h Tribolium castaneum 4
21314138 10.1021/jf104411h Rhyzopertha dominica 4
21314138 10.1021/jf104411h Sitophilus oryzae 4
21314138 10.1021/jf104411h Callosobruchus chinensis 4
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B3 3
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B1 3

Data from ChEMBL 36 via Core Engine