Compound Detail
CHEMBL1628243
LEVORPHANOL HYDROCHLORIDE Enter ChEMBL ID:
Free Research Context
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3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
257.4
MW (Da)
3.08
ALogP
2
HBA
1
HBD
23.5
PSA (Ų)
0.77
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 9.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mu-type opioid receptor CHEMBL4354 | Ki | 9.68 | 9.68 | 0.2 | 1 |
| Kappa-type opioid receptor CHEMBL3952 | Ki | 8.64 | 8.64 | 2.3 | 1 |
| Delta-type opioid receptor CHEMBL236 | Ki | 8.38 | 8.38 | 4.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | Ki | = | 0.21 | nM | 9.68 | Binding affinity towards Opioid receptor mu 1 by displacing the radioligand [3H]... | 10633042 |
| Kappa-type opioid receptor | Ki | = | 2.3 | nM | 8.64 | Binding affinity towards Opioid receptor kappa 1 by displacing the radioligand [... | 10633042 |
| Delta-type opioid receptor | Ki | = | 4.2 | nM | 8.38 | Binding affinity towards Opioid receptor delta 1 by displacing the radioligand [... | 10633042 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10633042 | 10.1021/jm9903343 | Mu-type opioid receptor | 1 |
| 10633042 | 10.1021/jm9903343 | Delta-type opioid receptor | 1 |
| 10633042 | 10.1021/jm9903343 | Kappa-type opioid receptor | 1 |
| 10633042 | 10.1021/jm9903343 | Opioid receptor (mu and kappa) | 1 |
| 10633042 | 10.1021/jm9903343 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine