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Compound Detail

CHEMBL1643586

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CCN(CC)Cc1ccc(-c2nc(CN(C3CCCC3)S(=O)(=O)c3ccc(OC)cc3)cs2)cc1

Basic Information

ChEMBL ID CHEMBL1643586
Phase Preclinical
Structure Type MOL
InChI Key QQOHHVBBSPVBNM-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

513.7
MW (Da)
5.79
ALogP
6
HBA
0
HBD
62.7
PSA (Ų)
0.32
QED
2
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H35N3O3S2
MW 513.73
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness -1.83

Activity Summary

Ki 3 meas. best 7.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vasopressin V1b receptor
CHEMBL1921
Ki 7.0 7.0 100.0 1
Vasopressin V1a receptor
CHEMBL1889
Ki 5.7 5.7 1995.3 1
Oxytocin receptor
CHEMBL2049
Ki 5.4 5.4 3981.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21146408 10.1016/j.bmcl.2010.11.061 Vasopressin V1b receptor 1
21146408 10.1016/j.bmcl.2010.11.061 Vasopressin V1a receptor 1
21146408 10.1016/j.bmcl.2010.11.061 Oxytocin receptor 1

Data from ChEMBL 36 via Core Engine