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Compound Detail

CHEMBL1643589

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COc1ccc(S(=O)(=O)N(Cc2csc(-c3ccc(CNCC4CCCCC4)cc3)n2)C2CCCC2)cc1

Basic Information

ChEMBL ID CHEMBL1643589
Phase Preclinical
Structure Type MOL
InChI Key LJDVQUIEOMPMNW-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

553.8
MW (Da)
6.62
ALogP
6
HBA
1
HBD
71.5
PSA (Ų)
0.29
QED
2
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H39N3O3S2
MW 553.79
Aromatic Rings 3
Heavy Atoms 38
NP-Likeness -1.59

Activity Summary

Ki 3 meas. best 6.5

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vasopressin V1b receptor
CHEMBL1921
Ki 6.5 6.5 316.2 1
Vasopressin V1a receptor
CHEMBL1889
Ki 5.5 5.5 3162.3 1
Oxytocin receptor
CHEMBL2049
Ki 5.2 5.2 6309.6 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21146408 10.1016/j.bmcl.2010.11.061 Vasopressin V1b receptor 1
21146408 10.1016/j.bmcl.2010.11.061 Vasopressin V1a receptor 1
21146408 10.1016/j.bmcl.2010.11.061 Oxytocin receptor 1

Data from ChEMBL 36 via Core Engine