Compound Detail
CHEMBL1667938
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CN(C)C(=O)[C@H]1CC[C@H](c2nc(-c3ccc4ccc(-c5ccccc5)nc4c3F)c3c(N)nccn32)CC1
Basic Information
| ChEMBL ID | CHEMBL1667938 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PKWNQLPXEORTDC-MEMLXQNLSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
508.6
MW (Da)
5.69
ALogP
6
HBA
1
HBD
89.4
PSA (Ų)
0.34
QED
2
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor CHEMBL1957 | IC50 | 7.57 | 7.57 | 27.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor | IC50 | = | 27.0 | nM | 7.57 | Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assay | 21251824 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21251824 | 10.1016/j.bmcl.2010.12.094 | Insulin-like growth factor 1 receptor | 1 |
Data from ChEMBL 36 via Core Engine