Assay Detail
Binding
CHEMBL1670374
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent and selective cyclohexyl-derived imidazopyrazine insulin-like growth factor 1 receptor inhibitors with in vivo efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.95 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1667943 | — | — | 1 | 8.70 |
| CHEMBL1667947 | — | — | 1 | 8.40 |
| CHEMBL1667945 | — | — | 1 | 8.30 |
| CHEMBL1667939 | — | — | 1 | 8.30 |
| CHEMBL1667941 | — | — | 1 | 8.30 |
| CHEMBL1667942 | — | — | 1 | 8.30 |
| CHEMBL1667948 | — | — | 1 | 8.22 |
| CHEMBL1667940 | — | — | 1 | 8.22 |
| CHEMBL1667936 | — | — | 1 | 8.10 |
| CHEMBL1667946 | — | — | 1 | 8.10 |
| CHEMBL1667950 | — | — | 1 | 7.85 |
| CHEMBL1667935 | — | — | 1 | 7.77 |
| CHEMBL249295 | — | — | 1 | 7.72 |
| CHEMBL1667944 | — | — | 1 | 7.70 |
| CHEMBL410659 | — | — | 1 | 7.70 |
| CHEMBL1667949 | — | — | 1 | 7.68 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 7.62 |
| CHEMBL1667938 | — | — | 1 | 7.57 |
| CHEMBL1667937 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1667943 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1667947 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1667945 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1667939 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1667941 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1667942 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1667948 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1667940 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1667936 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1667946 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1667950 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1667935 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL249295 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1667944 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL410659 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1667949 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1667938 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1667937 | — | IC50 | = | 285.0 | nM | 6.54 |