Compound Detail
CHEMBL1667950
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Cn1c(NC(=O)[C@H]2CC[C@H](c3nc(-c4ccc5ccc(-c6ccccc6)nc5c4F)c4c(N)nccn43)CC2)nc2ccccc21
Basic Information
| ChEMBL ID | CHEMBL1667950 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WYUNCPRJZROHRZ-RQNOJGIXSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
610.7
MW (Da)
7.13
ALogP
8
HBA
2
HBD
116.0
PSA (Ų)
0.21
QED
2
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor CHEMBL1957 | IC50 | 7.85 | 7.85 | 14.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor | IC50 | = | 14.0 | nM | 7.85 | Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assay | 21251824 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21251824 | 10.1016/j.bmcl.2010.12.094 | Insulin-like growth factor 1 receptor | 1 |
Data from ChEMBL 36 via Core Engine