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Compound Detail

CHEMBL1682918

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Cc1cccc(C(=O)c2nccc3c2[nH]c2ccccc23)c1

Basic Information

ChEMBL ID CHEMBL1682918
Phase Preclinical
Structure Type MOL
InChI Key KPSUVOLGQUFPHH-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

286.3
MW (Da)
4.26
ALogP
2
HBA
1
HBD
45.8
PSA (Ų)
0.56
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H14N2O
MW 286.33
Aromatic Rings 4
Heavy Atoms 22
NP-Likeness -0.13

Activity Summary

EC50 1 meas. best 6.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NON-PROTEIN TARGET
CHEMBL3879801
EC50 6.7 6.7 200.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
NON-PROTEIN TARGET EC50 = 200.0 nM 6.7 Antiinflammatory activity against mouse RAW246.7 cells assessed as inhibition of... 21316977

Literature References

Data from ChEMBL 36 via Core Engine