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Assay Detail

CHEMBL1687178

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiinflammatory activity against mouse RAW246.7 cells assessed as inhibition of lipopolysaccharide/interferon-gamma induced nitric oxide production
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis, in vitro anti-inflammatory and cytotoxic evaluation, and mechanism of action studies of 1-benzoyl-β-carboline and 1-benzoyl-3-carboxy-β-carboline derivatives.
Yang ML, Kuo PC, Hwang TL, Chiou WF, Qian K, Lai CY, Lee KH, Wu TS.
Bioorg Med Chem (2011) 19 : 1674 -1682
PubMed 21316977 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 31 5.86 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1682918 1 6.70
CHEMBL1682913 1 6.64
CHEMBL1682930 1 6.60
CHEMBL1682920 1 6.52
CHEMBL1681800 1 6.51
CHEMBL1682908 1 6.33
CHEMBL1682907 1 6.30
CHEMBL1682932 1 6.29
CHEMBL1682910 1 6.28
CHEMBL1682911 1 6.24
CHEMBL1682925 1 6.18
CHEMBL1682928 1 6.13
CHEMBL1651330 STELLARINES A 1 6.04
CHEMBL1682926 1 5.97
CHEMBL1682921 1 5.94
CHEMBL1682917 1 5.90
CHEMBL1682929 1 5.68
CHEMBL1682919 1 5.67
CHEMBL1682909 1 5.59
CHEMBL1682916 1 5.57
CHEMBL1682915 1 5.54
CHEMBL1682914 1 5.53
CHEMBL1682924 1 5.53
CHEMBL1682906 1 5.44
CHEMBL1682923 1 5.34
CHEMBL1682927 1 5.31
CHEMBL1682931 1 5.18
CHEMBL1682922 1 5.16
CHEMBL1682912 1 5.16
CHEMBL225304 PIMAGEDINE 2.0 1 4.65

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1682918 EC50 = 200.0 nM 6.70
CHEMBL1682913 EC50 = 230.0 nM 6.64
CHEMBL1682930 EC50 = 250.0 nM 6.60
CHEMBL1682920 EC50 = 300.0 nM 6.52
CHEMBL1681800 EC50 = 310.0 nM 6.51
CHEMBL1682908 EC50 = 470.0 nM 6.33
CHEMBL1682907 EC50 = 500.0 nM 6.30
CHEMBL1682932 EC50 = 510.0 nM 6.29
CHEMBL1682910 EC50 = 530.0 nM 6.28
CHEMBL1682911 EC50 = 570.0 nM 6.24
CHEMBL1682925 EC50 = 660.0 nM 6.18
CHEMBL1682928 EC50 = 740.0 nM 6.13
CHEMBL1651330 STELLARINES A EC50 = 920.0 nM 6.04
CHEMBL1682926 EC50 = 1060.0 nM 5.97
CHEMBL1682921 EC50 = 1160.0 nM 5.94
CHEMBL1682917 EC50 = 1260.0 nM 5.90
CHEMBL1682929 EC50 = 2080.0 nM 5.68
CHEMBL1682919 EC50 = 2120.0 nM 5.67
CHEMBL1682909 EC50 = 2580.0 nM 5.59
CHEMBL1682916 EC50 = 2670.0 nM 5.57
CHEMBL1682915 EC50 = 2880.0 nM 5.54
CHEMBL1682914 EC50 = 2940.0 nM 5.53
CHEMBL1682924 EC50 = 2960.0 nM 5.53
CHEMBL1682906 EC50 = 3650.0 nM 5.44
CHEMBL1682923 EC50 = 4590.0 nM 5.34
CHEMBL1682927 EC50 = 4940.0 nM 5.31
CHEMBL1682931 EC50 = 6650.0 nM 5.18
CHEMBL1682922 EC50 = 6970.0 nM 5.16
CHEMBL1682912 EC50 = 6960.0 nM 5.16
CHEMBL225304 PIMAGEDINE EC50 = 22600.0 nM 4.65
CHEMBL1682933 EC50 - -