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Compound Detail

CHEMBL1682921

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O=C(c1cccc(Br)c1)c1nccc2c1[nH]c1ccccc12

Basic Information

ChEMBL ID CHEMBL1682921
Phase Preclinical
Structure Type MOL
InChI Key UWCQMZCXNUYULW-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

351.2
MW (Da)
4.71
ALogP
2
HBA
1
HBD
45.8
PSA (Ų)
0.53
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H11BrN2O
MW 351.20
Aromatic Rings 4
Heavy Atoms 22
NP-Likeness -0.10

Activity Summary

EC50 1 meas. best 5.94

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NON-PROTEIN TARGET
CHEMBL3879801
EC50 5.94 5.94 1160.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
NON-PROTEIN TARGET EC50 = 1160.0 nM 5.94 Antiinflammatory activity against mouse RAW246.7 cells assessed as inhibition of... 21316977

Literature References

Data from ChEMBL 36 via Core Engine