Compound Detail
CHEMBL1688107
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C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O
Basic Information
| ChEMBL ID | CHEMBL1688107 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | VEIBXMZRLHAMLO-LANMVBEMSA-N |
4
Targets
8
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
1506.7
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 8 meas. best 9.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanocortin receptor 4 CHEMBL3719 | EC50 | 9.77 | 9.67 | 0.2 | 2 |
| Melanocyte-stimulating hormone receptor CHEMBL4077 | EC50 | 9.52 | 9.49 | 0.3 | 2 |
| Melanocortin receptor 5 CHEMBL4489 | EC50 | 8.84 | 8.74 | 1.4 | 2 |
| Melanocortin receptor 3 CHEMBL4774 | EC50 | 8.77 | 8.735 | 1.7 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21306168 | 10.1021/jm101425m | Melanocyte-stimulating hormone receptor | 1 |
| 21306168 | 10.1021/jm101425m | Melanocortin receptor 3 | 1 |
| 21306168 | 10.1021/jm101425m | Melanocortin receptor 4 | 1 |
| 21306168 | 10.1021/jm101425m | Melanocortin receptor 5 | 1 |
| 23432160 | 10.1021/jm301253y | Melanocortin receptor 5 | 1 |
| 23432160 | 10.1021/jm301253y | Melanocortin receptor 4 | 1 |
| 23432160 | 10.1021/jm301253y | Melanocortin receptor 3 | 1 |
| 23432160 | 10.1021/jm301253y | Melanocyte-stimulating hormone receptor | 1 |
Data from ChEMBL 36 via Core Engine