Compound Detail
CHEMBL1688758
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Basic Information
| ChEMBL ID | CHEMBL1688758 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XFHNVBGFUAYSEH-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
234.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.46 | 5.46 | 3500.0 | 1 |
| Trypanosoma brucei brucei CHEMBL612851 | IC50 | 5.42 | 5.42 | 3760.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 3500.0 | nM | 5.46 | Inhibition of Trypanosoma brucei TREU927 Leucyl-tRNA Synthetase expressed in Esc... | 21322634 |
| Trypanosoma brucei brucei | IC50 | = | 3760.0 | nM | 5.42 | Antitrypanosomal activity against bloodstream-form Trypanosoma brucei brucei 427... | 21322634 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21322634 | 10.1021/jm101225g | Unchecked | 1 |
| 21322634 | 10.1021/jm101225g | Trypanosoma brucei brucei | 1 |
| 21322634 | 10.1021/jm101225g | L929 | 1 |
Data from ChEMBL 36 via Core Engine