Assay Detail
Functional
CHEMBL1695093
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Antitrypanosomal activity against bloodstream-form Trypanosoma brucei brucei 427 after 72 hrs
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.88 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 8.30 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 7.58 |
| CHEMBL1688757 | — | — | 1 | 6.43 |
| CHEMBL1688741 | — | — | 1 | 6.14 |
| CHEMBL1688744 | — | — | 1 | 5.91 |
| CHEMBL1688756 | — | — | 1 | 5.68 |
| CHEMBL1688745 | — | — | 1 | 5.58 |
| CHEMBL1688760 | — | — | 1 | 5.56 |
| CHEMBL1688746 | — | — | 1 | 5.52 |
| CHEMBL1688758 | — | — | 1 | 5.42 |
| CHEMBL1688748 | — | — | 1 | 5.26 |
| CHEMBL1688754 | — | — | 1 | 5.08 |
| CHEMBL1688747 | — | — | 1 | 4.95 |
| CHEMBL1688755 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1688757 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1688741 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1688744 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL1688756 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL1688745 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL1688760 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL1688746 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1688758 | — | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL1688748 | — | IC50 | = | 5490.0 | nM | 5.26 |
| CHEMBL1688754 | — | IC50 | = | 8250.0 | nM | 5.08 |
| CHEMBL1688747 | — | IC50 | = | 11320.0 | nM | 4.95 |
| CHEMBL1688755 | — | IC50 | = | 12930.0 | nM | 4.89 |