Compound Detail
CHEMBL1688757
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Basic Information
| ChEMBL ID | CHEMBL1688757 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HTSBXZGMXWNQDE-UHFFFAOYSA-N |
3
Targets
5
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
234.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.43
EC50 2 meas. best 6.43
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma brucei CHEMBL612849 | EC50 | 6.43 | 6.43 | 370.0 | 2 |
| Trypanosoma brucei brucei CHEMBL612851 | IC50 | 6.43 | 6.43 | 370.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.3 | 5.3 | 5000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma brucei | EC50 | = | 370.0 | nM | 6.43 | Antitrypanosomal activity against Trypanosoma brucei assessed as growth inhibiti... | 21968372 |
| Trypanosoma brucei | EC50 | = | 370.0 | nM | 6.43 | Antiparasitic activity against Trypanosoma brucei infected in mouse L929 cells | 27080183 |
| Trypanosoma brucei brucei | IC50 | = | 370.0 | nM | 6.43 | Antitrypanosomal activity against bloodstream-form Trypanosoma brucei brucei 427... | 21322634 |
| Unchecked | IC50 | = | 5000.0 | nM | 5.3 | Inhibition of Trypanosoma brucei TREU927 Leucyl-tRNA Synthetase expressed in Esc... | 21322634 |
| Unchecked | IC50 | = | 5000.0 | nM | 5.3 | Inhibition of Trypanosoma brucei LeuRS assessed as formation of stable tRNA(Leu)... | 27080183 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21322634 | 10.1021/jm101225g | Unchecked | 1 |
| 21322634 | 10.1021/jm101225g | Trypanosoma brucei brucei | 1 |
| 21322634 | 10.1021/jm101225g | L929 | 1 |
| 21968372 | 10.1016/j.ejmech.2011.08.049 | Trypanosoma brucei | 1 |
| 27080183 | 10.1016/j.bmcl.2016.03.103 | Unchecked | 1 |
| 27080183 | 10.1016/j.bmcl.2016.03.103 | Trypanosoma brucei | 1 |
| 27080183 | 10.1016/j.bmcl.2016.03.103 | L929 | 1 |
Data from ChEMBL 36 via Core Engine