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Compound Detail

CHEMBL1712668

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Clc1ccc(-c2nc(-c3ccncc3)no2)c(Cl)c1

Basic Information

ChEMBL ID CHEMBL1712668
Phase Preclinical
Structure Type MOL
InChI Key XQNVKVJVJOHLED-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

292.1
MW (Da)
4.11
ALogP
4
HBA
0
HBD
51.8
PSA (Ų)
0.71
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H7Cl2N3O
MW 292.12
Aromatic Rings 3
Heavy Atoms 19
NP-Likeness -2.07

Activity Summary

IC50 1 meas. best 5.2

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Protein skinhead-1
CHEMBL2146298
IC50 5.2 5.2 6360.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Protein skinhead-1 IC50 = 6360.0 nM 5.2 PubChem BioAssay. Dose Response Confirmation of SKN-1 Inhibitor hits in a fluore... -

Literature References

PubMed DOI Target Context # Activities
24767852 10.1016/j.bmcl.2014.04.013 Aryl hydrocarbon receptor 1

Data from ChEMBL 36 via Core Engine