Compound Detail
CHEMBL1744066
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Basic Information
| ChEMBL ID | CHEMBL1744066 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BSCOBUWJGGMKMH-LLVKDONJSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
352.9
MW (Da)
1.22
ALogP
5
HBA
2
HBD
70.8
PSA (Ų)
0.80
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.43
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serotonin 3 (5-HT3) receptor CHEMBL2094116 | IC50 | 8.43 | 8.43 | 3.7 | 1 |
| D(2) dopamine receptor CHEMBL339 | IC50 | 6.2 | 6.2 | 637.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serotonin 3 (5-HT3) receptor | IC50 | = | 3.7 | nM | 8.43 | Concentration required to inhibit the binding of radioligand [3H]GR-65630 to ser... | 12593651 |
| D(2) dopamine receptor | IC50 | = | 637.0 | nM | 6.2 | Inhibition of the binding of radioligand [3H]spiperone to dopamine receptor D2 i... | 12593651 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12593651 | 10.1021/jm020270n | D(2) dopamine receptor | 1 |
| 12593651 | 10.1021/jm020270n | Serotonin 3 (5-HT3) receptor | 1 |
Data from ChEMBL 36 via Core Engine