Compound Detail
CHEMBL175761
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Basic Information
| ChEMBL ID | CHEMBL175761 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XNAFMJWSVTYBRV-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
335.4
MW (Da)
4.51
ALogP
5
HBA
0
HBD
68.9
PSA (Ų)
0.42
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 7.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL2243 | Ki | 7.66 | 7.66 | 22.0 | 2 |
| Fatty-acid amide hydrolase 1 CHEMBL3229 | Ki | 7.66 | 7.66 | 22.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | Ki | = | 22.0 | nM | 7.66 | Inhibitory constant determined against recombinant Fatty-acid amide hydrolase fr... | 15771430 |
| Fatty-acid amide hydrolase 1 | Ki | = | 22.0 | nM | 7.66 | Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamid... | 17279740 |
| Fatty-acid amide hydrolase 1 | Ki | = | 22.0 | nM | 7.66 | Inhibition of FAAH | 21764305 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15771430 | 10.1021/jm049614v | Fatty-acid amide hydrolase 1 | 1 |
| 17279740 | 10.1021/jm0611509 | Fatty-acid amide hydrolase 1 | 1 |
| 21764305 | 10.1016/j.bmcl.2011.06.096 | Fatty-acid amide hydrolase 1 | 1 |
Data from ChEMBL 36 via Core Engine