Compound Detail
CHEMBL1761457
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Basic Information
| ChEMBL ID | CHEMBL1761457 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RXVRDGZXPYUYJA-HXUWFJFHSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
469.6
MW (Da)
5.39
ALogP
7
HBA
1
HBD
67.1
PSA (Ų)
0.37
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL2243 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
| Fatty-acid amide hydrolase 1 CHEMBL3229 | IC50 | 7.41 | 7.41 | 39.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | IC50 | = | 2.0 | nM | 8.7 | Inhibition of human FAAH assessed as hydrolysis of anandamido-amino-methyl-cumar... | 21392988 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 39.0 | nM | 7.41 | Inhibition of rat FAAH assessed as hydrolysis of anandamido-amino-methyl-cumarin | 21392988 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21392988 | 10.1016/j.bmcl.2011.02.052 | Fatty-acid amide hydrolase 1 | 2 |
Data from ChEMBL 36 via Core Engine