Compound Detail
CHEMBL1766196
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Basic Information
| ChEMBL ID | CHEMBL1766196 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FMLCEUSRKWMBON-QMMMGPOBSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
362.3
MW (Da)
0.72
ALogP
8
HBA
4
HBD
148.4
PSA (Ų)
0.47
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 4.65
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus 2 CHEMBL380 | EC50 | 4.65 | 4.65 | 22400.0 | 1 |
| Human immunodeficiency virus 1 CHEMBL378 | EC50 | 4.38 | 4.38 | 41400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus 2 | EC50 | = | 22400.0 | nM | 4.65 | Antiviral activity against HIV2 ROD infected in human CEM cells assessed as inhi... | 21429755 |
| Human immunodeficiency virus 1 | EC50 | = | 41400.0 | nM | 4.38 | Antiviral activity against HIV1 3B infected in human CEM cells assessed as inhib... | 21429755 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21429755 | 10.1016/j.bmc.2011.02.050 | CCRF-CEM | 2 |
| 21429755 | 10.1016/j.bmc.2011.02.050 | Human immunodeficiency virus 1 | 1 |
| 21429755 | 10.1016/j.bmc.2011.02.050 | Human immunodeficiency virus 2 | 1 |
| 21429755 | 10.1016/j.bmc.2011.02.050 | Moloney murine sarcoma virus | 1 |
| 21429755 | 10.1016/j.bmc.2011.02.050 | Adenosine deaminase | 1 |
Data from ChEMBL 36 via Core Engine