Assay Detail
Functional
CHEMBL1768309
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human CEM cells assessed as inhibition of virus-induced syncytium formation after 4 to 5 days by microscopic analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 4.87 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2021513 | — | — | 1 | 5.64 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 5.34 |
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | 5.13 |
| CHEMBL1766194 | — | — | 1 | 4.85 |
| CHEMBL1766198 | — | — | 1 | 4.75 |
| CHEMBL1766195 | — | — | 1 | 4.59 |
| CHEMBL1766196 | — | — | 1 | 4.38 |
| CHEMBL1766275 | — | — | 1 | 4.29 |
| CHEMBL1766197 | — | — | 1 | - |
| CHEMBL1766199 | — | — | 1 | - |
| CHEMBL1766280 | — | — | 1 | - |
| CHEMBL1766279 | — | — | 1 | - |
| CHEMBL1766278 | — | — | 1 | - |
| CHEMBL1766277 | — | — | 1 | - |
| CHEMBL1766276 | — | — | 1 | - |
| CHEMBL1766274 | — | — | 1 | - |
| CHEMBL1766273 | — | — | 1 | - |
| CHEMBL1766201 | — | — | 1 | - |
| CHEMBL1766200 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2021513 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL484 | ADEFOVIR | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL1766194 | — | EC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL1766198 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1766195 | — | EC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL1766196 | — | EC50 | = | 41400.0 | nM | 4.38 |
| CHEMBL1766275 | — | EC50 | = | 51700.0 | nM | 4.29 |
| CHEMBL1766197 | — | EC50 | > | 276000.0 | nM | - |
| CHEMBL1766199 | — | EC50 | > | 247000.0 | nM | - |
| CHEMBL1766280 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1766279 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1766278 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1766277 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1766276 | — | EC50 | > | 255000.0 | nM | - |
| CHEMBL1766274 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1766273 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1766201 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1766200 | — | EC50 | > | 53000.0 | nM | - |