Compound Detail
CHEMBL17669
ENGLITAZONE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL17669 |
| Name | ENGLITAZONE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | MVDXXGIBARMXSA-PYUWXLGESA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
8
Publications
2
Known Names
Molecular Properties
353.4
MW (Da)
3.52
ALogP
4
HBA
1
HBD
55.4
PSA (Ų)
0.91
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Activity Summary
EC50 2 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma CHEMBL235 | EC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Peroxisome proliferator-activated receptor gamma CHEMBL2459 | EC50 | 4.89 | 4.89 | 13000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma | EC50 | = | 1000.0 | nM | 6.0 | Transactivation activity at Homo sapiens (human) PPARgamma | - |
| Peroxisome proliferator-activated receptor gamma | EC50 | = | 13000.0 | nM | 4.89 | In vitro transcriptional activation of Peroxisome proliferator activated recepto... | 8576907 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1992133 | 10.1021/jm00105a050 | Mus musculus | 4 |
| 1992133 | 10.1021/jm00105a050 | Unchecked | 3 |
| 1992133 | 10.1021/jm00105a050 | 3T3-L1 | 2 |
| 8576907 | 10.1021/jm950395a | Peroxisome proliferator-activated receptor gamma | 2 |
| - | 10.1016/S0960-894X(01)80325-5 | Mus musculus | 1 |
| 8576907 | 10.1021/jm950395a | Peroxisome proliferator-activated receptor alpha | 1 |
| 8576907 | 10.1021/jm950395a | Peroxisome proliferator-activated receptor delta | 1 |
| - | 10.1007/s00044-010-9428-9 | Peroxisome proliferator-activated receptor gamma | 1 |
Data from ChEMBL 36 via Core Engine