Assay Detail
Functional
CHEMBL760257
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro transcriptional activation of Peroxisome proliferator activated receptor gamma (PPAR) expressed in CV-1 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL2459) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.25 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17805 | BRL-48482 | — | 1 | 7.89 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 7.22 |
| CHEMBL128884 | — | — | 1 | 6.85 |
| CHEMBL297312 | — | — | 1 | 6.72 |
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | 6.16 |
| CHEMBL337973 | — | — | 1 | 6.00 |
| CHEMBL7002 | CIGLITAZONE | 2.0 | 1 | 5.52 |
| CHEMBL129562 | — | — | 1 | 5.00 |
| CHEMBL17669 | ENGLITAZONE | 2.0 | 1 | 4.89 |
| CHEMBL683 | CLOFIBRIC ACID | 2.0 | 1 | - |
| CHEMBL346267 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17805 | BRL-48482 | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL128884 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL297312 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL595 | PIOGLITAZONE | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL337973 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL7002 | CIGLITAZONE | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL129562 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL17669 | ENGLITAZONE | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL683 | CLOFIBRIC ACID | EC50 | = | 600000.0 | nM | - |
| CHEMBL346267 | — | EC50 | = | 110000.0 | nM | - |