Compound Detail
CHEMBL1783642
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CC[Si](CC)(c1ccc(OCC(=O)C(C)(C)C)c(C)c1)c1ccc(OCC(=O)C(C)(C)C)c(C)c1
Basic Information
| ChEMBL ID | CHEMBL1783642 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WEUQGGPXEFMBPZ-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
496.8
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.08
IC50 1 meas. best 5.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Androgen receptor CHEMBL1871 | IC50 | 5.21 | 5.21 | 6200.0 | 1 |
| Bovine viral diarrhea virus 1 CHEMBL612571 | EC50 | 5.08 | 5.08 | 8400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Androgen receptor | IC50 | = | 6200.0 | nM | 5.21 | Antagonist activity at human androgen receptor expressed in HEK293 cells assesse... | 23462715 |
| Bovine viral diarrhea virus 1 | EC50 | = | 8400.0 | nM | 5.08 | Antiviral activity against BVDV1 Nose infected in MDBK cells assessed as inhibit... | 19447037 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23462715 | 10.1016/j.bmc.2013.01.060 | Androgen receptor | 2 |
| 19447037 | 10.1016/j.bmcl.2009.04.137 | Bovine viral diarrhea virus 1 | 1 |
| 19447037 | 10.1016/j.bmcl.2009.04.137 | ADMET | 1 |
| 23462715 | 10.1016/j.bmc.2013.01.060 | Unchecked | 1 |
| 23462715 | 10.1016/j.bmc.2013.01.060 | Vitamin D3 receptor | 1 |
Data from ChEMBL 36 via Core Engine