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Compound Detail

CHEMBL1796038

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O=C1CC(c2ccc(Cl)cc2)CC(=O)N1CCN1CCN(c2ccccc2Cl)CC1

Basic Information

ChEMBL ID CHEMBL1796038
Phase Preclinical
Structure Type MOL
InChI Key OCLXFGLODKGRRE-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

446.4
MW (Da)
4.05
ALogP
4
HBA
0
HBD
43.9
PSA (Ų)
0.65
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H25Cl2N3O2
MW 446.38
Aromatic Rings 2
Heavy Atoms 30
NP-Likeness -1.37

Activity Summary

Ki 3 meas. best 5.82

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Alpha-1D adrenergic receptor
CHEMBL223
Ki 5.82 5.82 1513.6 1
Alpha-1A adrenergic receptor
CHEMBL229
Ki 5.16 5.16 6918.3 1
Alpha-1B adrenergic receptor
CHEMBL232
Ki 5.0 5.0 10000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21514979 10.1016/j.ejmech.2011.03.054 Alpha-1A adrenergic receptor 1
21514979 10.1016/j.ejmech.2011.03.054 Alpha-1B adrenergic receptor 1
21514979 10.1016/j.ejmech.2011.03.054 Alpha-1D adrenergic receptor 1

Data from ChEMBL 36 via Core Engine