Assay Detail
Binding
CHEMBL1798145
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Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 4-phenylpiperidine-2,6-dione derivatives. Ligands for α₁-adrenoceptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 7.23 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56438 | — | — | 1 | 9.89 |
| CHEMBL301707 | — | — | 1 | 9.44 |
| CHEMBL1796046 | — | — | 1 | 7.84 |
| CHEMBL1796033 | — | — | 1 | 7.80 |
| CHEMBL1796050 | — | — | 1 | 7.79 |
| CHEMBL319972 | — | — | 1 | 7.70 |
| CHEMBL1796036 | — | — | 1 | 7.51 |
| CHEMBL1796034 | — | — | 1 | 7.47 |
| CHEMBL100434 | — | — | 1 | 7.45 |
| CHEMBL1796035 | — | — | 1 | 7.41 |
| CHEMBL1796031 | — | — | 1 | 7.36 |
| CHEMBL1796030 | — | — | 1 | 7.34 |
| CHEMBL1796044 | — | — | 1 | 7.29 |
| CHEMBL1796043 | — | — | 1 | 7.27 |
| CHEMBL95191 | — | — | 1 | 7.22 |
| CHEMBL1796040 | — | — | 1 | 7.20 |
| CHEMBL1796042 | — | — | 1 | 7.17 |
| CHEMBL1796039 | — | — | 1 | 7.16 |
| CHEMBL1796041 | — | — | 1 | 7.14 |
| CHEMBL1796049 | — | — | 1 | 7.12 |
| CHEMBL1796047 | — | — | 1 | 7.11 |
| CHEMBL1796045 | — | — | 1 | 7.01 |
| CHEMBL330198 | — | — | 1 | 6.61 |
| CHEMBL1796032 | — | — | 1 | 6.41 |
| CHEMBL1796029 | — | — | 1 | 6.20 |
| CHEMBL1796037 | — | — | 1 | 6.16 |
| CHEMBL1796048 | — | — | 1 | 6.04 |
| CHEMBL1796028 | — | — | 1 | 5.88 |
| CHEMBL1796038 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56438 | — | Ki | = | 0.1288 | nM | 9.89 |
| CHEMBL301707 | — | Ki | = | 0.3631 | nM | 9.44 |
| CHEMBL1796046 | — | Ki | = | 14.45 | nM | 7.84 |
| CHEMBL1796033 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL1796050 | — | Ki | = | 16.22 | nM | 7.79 |
| CHEMBL319972 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL1796036 | — | Ki | = | 30.9 | nM | 7.51 |
| CHEMBL1796034 | — | Ki | = | 33.88 | nM | 7.47 |
| CHEMBL100434 | — | Ki | = | 35.48 | nM | 7.45 |
| CHEMBL1796035 | — | Ki | = | 38.9 | nM | 7.41 |
| CHEMBL1796031 | — | Ki | = | 43.65 | nM | 7.36 |
| CHEMBL1796030 | — | Ki | = | 45.71 | nM | 7.34 |
| CHEMBL1796044 | — | Ki | = | 51.29 | nM | 7.29 |
| CHEMBL1796043 | — | Ki | = | 53.7 | nM | 7.27 |
| CHEMBL95191 | — | Ki | = | 60.26 | nM | 7.22 |
| CHEMBL1796040 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL1796042 | — | Ki | = | 67.61 | nM | 7.17 |
| CHEMBL1796039 | — | Ki | = | 69.18 | nM | 7.16 |
| CHEMBL1796041 | — | Ki | = | 72.44 | nM | 7.14 |
| CHEMBL1796049 | — | Ki | = | 75.86 | nM | 7.12 |
| CHEMBL1796047 | — | Ki | = | 77.62 | nM | 7.11 |
| CHEMBL1796045 | — | Ki | = | 97.72 | nM | 7.01 |
| CHEMBL330198 | — | Ki | = | 245.47 | nM | 6.61 |
| CHEMBL1796032 | — | Ki | = | 389.05 | nM | 6.41 |
| CHEMBL1796029 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL1796037 | — | Ki | = | 691.83 | nM | 6.16 |
| CHEMBL1796048 | — | Ki | = | 912.01 | nM | 6.04 |
| CHEMBL1796028 | — | Ki | = | 1318.26 | nM | 5.88 |
| CHEMBL1796038 | — | Ki | = | 1513.56 | nM | 5.82 |