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Compound Detail

CHEMBL1796049

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COc1ccccc1N1CCN(CCCN2C(=O)CC3(CCc4ccccc43)CC2=O)CC1

Basic Information

ChEMBL ID CHEMBL1796049
Phase Preclinical
Structure Type MOL
InChI Key DIHJKGKNVGCNHJ-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

447.6
MW (Da)
3.24
ALogP
5
HBA
0
HBD
53.1
PSA (Ų)
0.64
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H33N3O3
MW 447.58
Aromatic Rings 2
Heavy Atoms 33
NP-Likeness -0.86

Activity Summary

Ki 3 meas. best 7.2

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Alpha-1A adrenergic receptor
CHEMBL229
Ki 7.2 7.2 63.1 1
Alpha-1D adrenergic receptor
CHEMBL223
Ki 7.12 7.12 75.9 1
Alpha-1B adrenergic receptor
CHEMBL232
Ki 6.63 6.63 234.4 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21514979 10.1016/j.ejmech.2011.03.054 Alpha-1A adrenergic receptor 1
21514979 10.1016/j.ejmech.2011.03.054 Alpha-1B adrenergic receptor 1
21514979 10.1016/j.ejmech.2011.03.054 Alpha-1D adrenergic receptor 1

Data from ChEMBL 36 via Core Engine