Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL1796044

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
COc1ccccc1N1CCN(CCCN2C(=O)CC(C)(c3ccccc3)CC2=O)CC1

Basic Information

ChEMBL ID CHEMBL1796044
Phase Preclinical
Structure Type MOL
InChI Key NBBAMPGWOJEMGG-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

435.6
MW (Da)
3.31
ALogP
5
HBA
0
HBD
53.1
PSA (Ų)
0.62
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H33N3O3
MW 435.57
Aromatic Rings 2
Heavy Atoms 32
NP-Likeness -0.81

Activity Summary

Ki 3 meas. best 7.99

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Alpha-1A adrenergic receptor
CHEMBL229
Ki 7.99 7.99 10.2 1
Alpha-1D adrenergic receptor
CHEMBL223
Ki 7.29 7.29 51.3 1
Alpha-1B adrenergic receptor
CHEMBL232
Ki 6.89 6.89 128.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21514979 10.1016/j.ejmech.2011.03.054 Alpha-1A adrenergic receptor 1
21514979 10.1016/j.ejmech.2011.03.054 Alpha-1B adrenergic receptor 1
21514979 10.1016/j.ejmech.2011.03.054 Alpha-1D adrenergic receptor 1

Data from ChEMBL 36 via Core Engine