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Compound Detail

CHEMBL1807819

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O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCCOCCc3ccccc3)c2s1

Basic Information

ChEMBL ID CHEMBL1807819
Phase Preclinical
Structure Type MOL
InChI Key KRCTVIVPCMLXBB-FQEVSTJZSA-N
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

462.6
MW (Da)
3.69
ALogP
7
HBA
4
HBD
94.6
PSA (Ų)
0.27
QED
0
Ro5 Violations
14
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H30N2O4S2
MW 462.64
Aromatic Rings 3
Heavy Atoms 31
NP-Likeness -0.41

Activity Summary

EC50 2 meas. best 10.1
IC50 2 meas. best 8.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 10.1 10.1 0.1 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 8.4 8.4 4.0 1
Beta-1 adrenergic receptor
CHEMBL213
IC50 8.4 8.4 4.0 1
D(2) dopamine receptor
CHEMBL217
IC50 6.2 6.2 631.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21723724 10.1016/j.bmcl.2011.05.097 Unchecked 3
21723724 10.1016/j.bmcl.2011.05.097 Beta-1 adrenergic receptor 2
21723724 10.1016/j.bmcl.2011.05.097 Beta-2 adrenergic receptor 2
21723724 10.1016/j.bmcl.2011.05.097 D(2) dopamine receptor 1
21723724 10.1016/j.bmcl.2011.05.097 No relevant target 1

Data from ChEMBL 36 via Core Engine