Compound Detail
CHEMBL1822377
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Basic Information
| ChEMBL ID | CHEMBL1822377 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XFSPUECBJISPDO-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
320.3
MW (Da)
3.39
ALogP
5
HBA
1
HBD
63.8
PSA (Ų)
0.63
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.66
Ki 1 meas. best 6.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 6.66 | 6.66 | 220.0 | 1 |
| Hepatocyte growth factor receptor CHEMBL3717 | Ki | 6.4 | 6.4 | 400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 220.0 | nM | 6.66 | Inhibition of human c-MET | 21641696 |
| Hepatocyte growth factor receptor | Ki | = | 400.0 | nM | 6.4 | Inhibition of c-Met (unknown origin) using poly Glu-Tyr as substrate preincubate... | 34141080 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34141080 | 10.1021/acsmedchemlett.1c00094 | Hepatocyte growth factor receptor | 2 |
| 34141080 | 10.1021/acsmedchemlett.1c00094 | ADMET | 2 |
| 21641696 | 10.1016/j.ejmech.2011.05.031 | Hepatocyte growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine