Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL185967

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
Nc1nc(N2CCN(Cc3cc4ccccc4nc3Cl)CC2)nc2nc(-c3ccco3)nn12

Basic Information

ChEMBL ID CHEMBL185967
Phase Preclinical
Structure Type MOL
InChI Key BFHTYTKAGXGUKJ-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
2
PK Parameters
5
Publications
0
Known Names

Molecular Properties

461.9
MW (Da)
2.89
ALogP
10
HBA
1
HBD
114.5
PSA (Ų)
0.40
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H20ClN9O
MW 461.92
Aromatic Rings 5
Heavy Atoms 33
NP-Likeness -1.91

Activity Summary

Ki 2 meas. best 8.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A2a
CHEMBL302
Ki 8.22 8.22 6.0 1
Adenosine receptor A1
CHEMBL318
Ki 6.6 6.6 250.0 1

Pharmacokinetic Data

Parameter Value Units Species
F 59.0 % Rattus norvegicus
T1/2 1.4 hr Rattus norvegicus

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15294001 10.1021/jm0498405 Rattus norvegicus 4
15294001 10.1021/jm0498405 Adenosine receptor A2a 1
15294001 10.1021/jm0498405 Adenosine receptor A1 1
15294001 10.1021/jm0498405 Mus musculus 1
15294001 10.1021/jm0498405 ADMET 1

Data from ChEMBL 36 via Core Engine