Compound Detail
CHEMBL1863490
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Basic Information
| ChEMBL ID | CHEMBL1863490 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OGNJIBCQHDUCGH-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
396.5
MW (Da)
3.94
ALogP
4
HBA
1
HBD
69.0
PSA (Ų)
0.71
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma cruzi CHEMBL368 | IC50 | 7.62 | 7.62 | 24.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma cruzi | IC50 | = | 24.0 | nM | 7.62 | DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Cl... | - |
| Trypanosoma cruzi | IC50 | = | 24.0 | nM | 7.62 | DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Cl... | - |
| Trypanosoma cruzi | IC50 | = | 24.0 | nM | 7.62 | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 6 amastigotes infec... | 24304150 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL1862790 | Trypanosoma cruzi | 4 |
| - | 10.6019/CHEMBL1862790 | L6 | 2 |
| 24304150 | 10.1021/jm401610c | Trypanosoma cruzi | 2 |
| 24304150 | 10.1021/jm401610c | Plasma | 2 |
| 24304150 | 10.1021/jm401610c | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine