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Assay Detail

CHEMBL3107754

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 6 amastigotes infected in rat L6 cells after 96 hrs by colorimetric method
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Two analogues of fenarimol show curative activity in an experimental model of Chagas disease.
Keenan M, Chaplin JH, Alexander PW, Abbott MJ, Best WM, Khong A, Botero A, Perez C, Cornwall S, Thompson RA, White KL, Shackleford DM, Koltun M, Chiu FC, Morizzi J, Ryan E, Campbell M, von Geldern TW, Scandale I, Chatelain E, Charman SA.
J Med Chem (2013) 56 : 10158 -10170
PubMed 24304150 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 47 7.99 9.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3104531 1 9.22
CHEMBL3104528 1 9.22
CHEMBL1397 POSACONAZOLE 4.0 1 9.00
CHEMBL1863325 1 8.70
CHEMBL3104477 1 8.70
CHEMBL3104478 1 8.70
CHEMBL3104490 1 8.70
CHEMBL3104476 1 8.52
CHEMBL3104529 1 8.52
CHEMBL3104537 1 8.52
CHEMBL3104479 1 8.30
CHEMBL3104376 1 8.15
CHEMBL3104526 1 8.15
CHEMBL3104534 1 8.15
CHEMBL3104538 1 8.15
CHEMBL3104486 1 8.10
CHEMBL3104530 1 8.10
CHEMBL3104532 1 8.05
CHEMBL1863286 1 7.96
CHEMBL3104488 1 7.92
CHEMBL1863379 1 7.92
CHEMBL3104489 1 7.92
CHEMBL3104485 1 7.92
CHEMBL1863267 1 7.89
CHEMBL3104473 1 7.82
CHEMBL3104535 1 7.82
CHEMBL3104484 1 7.82
CHEMBL3104536 1 7.77
CHEMBL3104375 1 7.77
CHEMBL1863275 1 7.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3104531 IC50 = 0.6 nM 9.22
CHEMBL3104528 IC50 = 0.6 nM 9.22
CHEMBL1397 POSACONAZOLE IC50 = 1.0 nM 9.00
CHEMBL1863325 IC50 = 2.0 nM 8.70
CHEMBL3104477 IC50 = 2.0 nM 8.70
CHEMBL3104478 IC50 = 2.0 nM 8.70
CHEMBL3104490 IC50 = 2.0 nM 8.70
CHEMBL3104476 IC50 = 3.0 nM 8.52
CHEMBL3104529 IC50 = 3.0 nM 8.52
CHEMBL3104537 IC50 = 3.0 nM 8.52
CHEMBL3104479 IC50 = 5.0 nM 8.30
CHEMBL3104534 IC50 = 7.0 nM 8.15
CHEMBL3104538 IC50 = 7.0 nM 8.15
CHEMBL3104526 IC50 = 7.0 nM 8.15
CHEMBL3104376 IC50 = 7.0 nM 8.15
CHEMBL3104486 IC50 = 8.0 nM 8.10
CHEMBL3104530 IC50 = 8.0 nM 8.10
CHEMBL3104532 IC50 = 9.0 nM 8.05
CHEMBL1863286 IC50 = 11.0 nM 7.96
CHEMBL3104488 IC50 = 12.0 nM 7.92
CHEMBL1863379 IC50 = 12.0 nM 7.92
CHEMBL3104489 IC50 = 12.0 nM 7.92
CHEMBL3104485 IC50 = 12.0 nM 7.92
CHEMBL1863267 IC50 = 13.0 nM 7.89
CHEMBL3104535 IC50 = 15.0 nM 7.82
CHEMBL3104484 IC50 = 15.0 nM 7.82
CHEMBL3104473 IC50 = 15.0 nM 7.82
CHEMBL3104536 IC50 = 17.0 nM 7.77
CHEMBL3104375 IC50 = 17.0 nM 7.77
CHEMBL1863275 IC50 = 19.0 nM 7.72
CHEMBL3104533 IC50 = 21.0 nM 7.68
CHEMBL3104487 IC50 = 21.0 nM 7.68
CHEMBL3104472 IC50 = 22.0 nM 7.66
CHEMBL3104474 IC50 = 24.0 nM 7.62
CHEMBL3104374 IC50 = 24.0 nM 7.62
CHEMBL1863490 IC50 = 24.0 nM 7.62
CHEMBL1863145 IC50 = 35.0 nM 7.46
CHEMBL3104475 IC50 = 39.0 nM 7.41
CHEMBL1863363 IC50 = 47.0 nM 7.33
CHEMBL3104480 IC50 = 50.0 nM 7.30
CHEMBL3104481 IC50 = 51.0 nM 7.29
CHEMBL1863467 IC50 = 58.0 nM 7.24
CHEMBL1862986 IC50 = 61.0 nM 7.21
CHEMBL3104482 IC50 = 65.0 nM 7.19
CHEMBL3104527 IC50 > 100.0 nM -
CHEMBL3104525 IC50 > 100.0 nM -
CHEMBL3104483 IC50 > 100.0 nM -