Compound Detail
CHEMBL188176
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Basic Information
| ChEMBL ID | CHEMBL188176 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GVCDQMYEZBECJU-FQEVSTJZSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
337.5
MW (Da)
5.34
ALogP
2
HBA
0
HBD
12.5
PSA (Ų)
0.68
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.83
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A CHEMBL273 | Ki | 8.83 | 8.83 | 1.5 | 1 |
| 5-hydroxytryptamine receptor 7 CHEMBL3223 | Ki | 7.91 | 7.91 | 12.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Ki | = | 1.49 | nM | 8.83 | Inhibition of [3H]8-OH-DPAT binding to rat 5-hydroxytryptamine 1A receptor | 15267230 |
| 5-hydroxytryptamine receptor 7 | Ki | = | 12.4 | nM | 7.91 | Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor | 15267230 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15267230 | 10.1021/jm0498102 | 5-hydroxytryptamine receptor 7 | 2 |
| 15267230 | 10.1021/jm0498102 | 5-hydroxytryptamine receptor 1A | 1 |
| 15267230 | 10.1021/jm0498102 | D(2) dopamine receptor | 1 |
| 15267230 | 10.1021/jm0498102 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine